From MedPage Today
Vitamin E Slows Decline in Alzheimer's
Published: Jan 2, 2014
By John Gever, Deputy Managing Editor, MedPage Today
Reviewed by F. Perry Wilson, MD, MSCE; Instructor of Medicine, Perelman School of Medicine at the University of Pennsylvania
Older veterans with mild to moderate Alzheimer's disease who took vitamin E supplements in a randomized trial showed less progression of functional impairment, researchers said.
With mean follow-up of 2.27 years (SD 1.22), the 140 patients assigned to daily supplements of 2,000 IU of vitamin E (alpha tocopherol) had mean declines in Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS-ADL) scores of 13.81 points (SD 1.11), compared with a drop of 16.96 points (SD 1.11) in a placebo group, reported Maurice Dysken, MD, of the Minneapolis VA Health System, and colleagues.
The difference of 3.15 points was statistically significant (95% CI 0.92-5.39), the researchers reported in the Jan. 1 issue of the Journal of the American Medical Association. It remained significant after adjusting for baseline factors, with a P value of 0.03.
Read more from MedPage Today >>
Vitamin E Slows Decline in Alzheimer's
Published: Jan 2, 2014
By John Gever, Deputy Managing Editor, MedPage Today
Reviewed by F. Perry Wilson, MD, MSCE; Instructor of Medicine, Perelman School of Medicine at the University of Pennsylvania
Older veterans with mild to moderate Alzheimer's disease who took vitamin E supplements in a randomized trial showed less progression of functional impairment, researchers said.
With mean follow-up of 2.27 years (SD 1.22), the 140 patients assigned to daily supplements of 2,000 IU of vitamin E (alpha tocopherol) had mean declines in Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS-ADL) scores of 13.81 points (SD 1.11), compared with a drop of 16.96 points (SD 1.11) in a placebo group, reported Maurice Dysken, MD, of the Minneapolis VA Health System, and colleagues.
The difference of 3.15 points was statistically significant (95% CI 0.92-5.39), the researchers reported in the Jan. 1 issue of the Journal of the American Medical Association. It remained significant after adjusting for baseline factors, with a P value of 0.03.
Read more from MedPage Today >>
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